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Effects of Procyanidine on Rats Treated by Iron Overload
under Condition of Simulated Weightlessness
WANG Aidong
1
,摇 CHEN Pu
2
,摇 HUANG Luyao
1
,摇 ZANG Jiachen
1
,摇 ZHAO Guanghua
1,2,*
(1
. College of Food Science and Nutritional Engineering
,
China Agricultural University
,
Beijing
100083,
China
;
2
. Key Laboratory of Space Nutrition and Food Engineering
,
China Astronaut Research and Training Center
,
Beijing
100094,
China
)
Abstract
: The study aimed to investigate effects of procyanidine on rats treated by iron overload under the
condition of simulated weightlessness. Simulated weightlessness was simulated by hind limb unloading
rats, which maintained about - 30毅 head down tilt position and freely took food and water. Iron overload
was administrated by giving 5 doses (one dose every two days) intraperitoneal injection of iron鄄dextran at
a dose of 100 mg / (kg·bodyweight) while correspondingly the other rats received the isovolumic injection
of saline. Treatment of procyanidine was conducted by gavage of procyanidine dissolved in water at a dose
of 40 mg / (d·(kg·bodyweight)
- 1
) . After 11鄄day treatment, the changes of body weight, concentration
of hemoglobin, and serum ferritin were sued to estimate the models. Body weight, concentration of hemo鄄
globin, red blood cell, serum ferritin, liver sections, and femur were used to estimate the effects of pro鄄
cyanidine on rats. Results showed that iron overload and simulated weightlessness had synergetic effects
on the health of rats. Procyanidine did not inhibit the decrease of body weight, the increase of hemoglo鄄
bin and serum ferritin, the iron deposition in liver, and the loss of bone volume fraction induced by iron
overload under the condition of simulated weightlessness.
Key words
: procyanidine; simulated weightlessness; iron overload
(
责任编辑
:
叶红波
)
13
第
33
卷 第
1
期
摇 摇 摇 摇 摇 摇 摇 摇 摇 摇
王爱东等
:
原花青素对模拟失重条件下大鼠体内铁过载的影响
