步分析可以见到
,
原花青素处理在对照组
、
高铁组
、
模拟失重组和高铁与模拟失重组均未对大鼠骨小梁
的数量
、
厚度以及间隙产生影响
,
说明原花青素处理
未能够改变模拟失重条件下过量铁对大鼠股骨造成
的不良影响
。
原花青素未改变模拟失重条件下铁过载引起的
大鼠铁调素水平升高
。
铁调素是由肝脏产生的肽类
激素
,
用于调节机体铁水平
。
当机体铁水平升高时
,
肝脏分泌铁调素增加
,
铁调素能够结合在细胞表面
膜铁转运蛋白
(Fpn)
上
,
引起其内化和降解
,
阻止细胞
铁释放
,
从而达到降低机体铁水平的目的
[16]
。
从图
5
中可以看到
,
原花青素处理未对由铁过载以及高铁与
模拟失重联合模型处理引起的大鼠体内铁调素水平升
高产生缓解作用
。
这也进一步证明了原花青素在本研
究中未能够改变大鼠体内铁过载的状况
。
4摇
结
摇
论
本研究探究了原花青素对模拟失重条件下铁过
载对大鼠的影响
。
通过体重监测
,
血红蛋白
、
红细胞
和血清铁蛋白
,
肝脏铁沉积和股骨健康状况分析
,
发
现
:
首先
,
铁过载和模拟失重处理危害大鼠的健康
,
并且二者在抑制大鼠体重增长
,
增加大鼠血清铁蛋
白
,
增加大鼠骨小梁间隙
,
增加大鼠血清铁调素含量
这些指标上存在协同效应
;
其次
,
原花青素处理未能
够改善模拟失重条件下铁过载对大鼠的不良影响
。
这也说明原花青素作为抗氧化剂在本实验条件下不
会产生其他副作用
。
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03
食品科学技术学报
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摇 2015
年
1
月
