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Research Progress on Microbial Production of Flavonoids
CHEN Jian
1,2
,摇 ZHOU Shenghu
1
,摇 WU Junjun
1
,摇 ZHOU Jingwen
1,*
,摇 DU Guocheng
1,2
(1
. School of Biological Engineering
,
Jiangnan University
,
Wuxi
214122,
China
;
2
. State Key Laboratory of Food Science and Technology
,
Jiangnan University
,
Wuxi
214122,
China
)
Abstract
: Flavonoids are plant secondary metabolites, which are valuable natural products widely used in
human health and nutrition due to its biochemical properties such as antiviral, antiobesity, and antican鄄
cer. The efficient production of pure flavonoid compounds through plant extraction or chemical production
continues to be a major challenge for drug development. Hence, the microbial production of flavonoids
has emerged as an interesting and commercially attractive approach. The emergence of systems metabolic
engineering offers new perspectives on strain and process optimization. In this review, the strategies of
systems metabolic engineering used to overcome these challenges are summarized, which will offer in鄄
sights into overcoming the limitations and challenges of large鄄scale microbial production of these important
pharmaceutical compounds.
Key words
: metabolic engineering; flavonoids; skeleton substance;
Escherichia coli
;
Saccharomyces cer鄄
evisiae
(
责任编辑
:
叶红波
)
5
第
33
卷 第
1
期
摇 摇 摇 摇 摇 摇 摇 摇 摇 摇
陈
摇
坚等
:
微生物合成黄酮类化合物的研究进展
