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第 38 卷 第 5 期摇 摇 摇 摇 摇 摇 摇 摇 陈摇 梦等: 降血压活性卡拉胶钾的肠道菌群调节作用研究 5 5

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Study on Regulation Effect on Intestinal Flora of Potassium
Carrageenan with Hypotensive Activity

1 1 1 1,* 2,*
CHEN Meng ,摇 FU Xiaodan ,摇 ZHU Changliang ,摇 MOU Haijin ,摇 HAN Zhenlian
(1. College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China;
2. School of Life Science, Huaiyin Normal University, Huaian 223300, China)

Abstract: In order to study the hypotensive mechanism of combination product of 资鄄carrageenan and
potassium, the effect of low鄄molecular weight carrageenan potassium (LCP) on intestinal flora regulation
was studied using high鄄throughput sequencing and bioinformatics analysis. Experiments indicated that
LCP had a stable and sustained antihypertensive effect on spontaneously hypertensive rats. Compared with
that in control group, the final depressurizing amplitude was about 18 mmHg (2郾 3 kPa). Through
analyzing the types and concentrations of short鄄chain fatty acids in contents of cecum, it was found that
the content of acetic acid, isobutyric acid, and butyric acid in LCP group was significantly higher than
that in blank group, and the variation of isobutyric acid production was particularly obvious. The 16S
rRNA sequencing results of cecum contents showed that compared with the blank group, the F/ B value of
the LCP group was reduced, the bacterial abundance was increased, and the number of Ruminococcus
which producing butyric acid was dominant. Overall, the results indicated that LCP could be used as a
regulator of intestinal microbiota, realized to promote the healthy recovery of intestinal disregulation and
therapeutic of hypertension.

Keywords: low鄄molecular weight potassium carrageenan; hypotensive activity; intestinal flora; short鄄
chain fatty acids; intestinal environment
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