Page 88 - 《食品科学技术学报》2020年第5期

第 38 卷 第 5 期摇 摇 摇 摇 摇 摇 摇 李摇 祥等: 黑米花青素对高脂膳食小鼠的空间学习记忆能力的影响 8 3

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不同字母表示存在显著性差异(P < 0郾 05)。 fat diet causes aging like neuropathological changes in
图 5摇 黑米花青素对小鼠大脑炎症相关 non鄄aged mice brain[J]. Brain Research Bulletin, 2019,
基因 mRNA 表达的影响 147:148 - 158.
Fig. 5摇 mRNA expression of inflammation [7]摇 CAREY A N, GOMES S M, SHUKITT鄄HALE B. Blue鄄
related genes in brain berry supplementation improves memory in middle鄄aged
摇
mice fed a high鄄fat diet [ J]. Journal Agricultural Food
(P < 0郾 05), 穿 越 隐 蔽 的 次 数 也 显 著 增 加 ( P <
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0郾 05),且与黑米花青素有剂量效应关系,表明了黑
[8]摇 WU T, GUO X, ZHANG M, et al. Anthocyanins in
米花青素可以改善高脂膳食引起的学习和记忆能力
black rice, soybean and purple corn increase fecal butyric
损伤。 acid and prevent liver inflammation in high fat diet鄄in鄄
高脂饮食可增加了小鼠脑组织中氧化应激水 duced obese mice[J]. Food and Function, 2017,8(9):
平。 经过 200 mg / kg 黑米花青素干预后,小鼠海马 3178 - 3186.

体中 MDA 含量显著降低(P < 0郾 05),SOD 和 GSH鄄 [9]摇 LI D, WANG P, LUO Y, et al. Health benefits of antho鄄
Px 活力显著提高 ( P < 0郾 05), DA 含量显著提高 cyanins and molecular mechanisms: update from recent
(P < 0郾 05),IL鄄1茁、TNF琢 和 COX鄄2 基因表达水平亦 decade[J]. Critical Reviews in Food Science and Nutri鄄
显著降低(P < 0郾 05),表明黑米花青素的干预后会 tion, 2017,57(8):1729 - 1741.
[10]摇 MORRIS R. Developments of a water鄄maze procedure
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本研究证实了长期高脂膳食导致慢性氧化应激
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损伤了小鼠的空间学习记忆功能,膳食补充黑米花
for spatial learning in the Morris water maze[J]. Journal
青素可改善小鼠的空间学习记忆能力,其机制可能 of Neurosci Methods, 2019,318:1 - 5.
是通过改善脑组织氧化应激状态和降低炎症水平实 [12]摇 LEE M R, KIM J E, CHOI J Y, et al. Anti鄄obesity

现的。 effect in high鄄fat鄄diet鄄induced obese C57BL/ 6 mice:
study of a novel extract from mulberry ( Morus alba)
参考文献: leaves fermented with Cordyceps militaris [ J]. Experi鄄
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