Page 106 - 《食品科学技术学报》2020年第3期

第 38 卷 第 3 期摇 摇 摇 摇 摇 王摇 然等: 灭活型副干酪乳杆菌 L9 常温酸奶调节肠道菌群缓解便秘作用研究 1 0 1

Technology, 2016, 16(8): 38 - 44. fed rats by modulation of gut microbiota [ J]. Food &
[18]摇 KOH A, DE VADDER F, KOVATCHEVA鄄DAT鄄 Function, 2017, 8(12): 4644 - 4656.
CHARY P, et al. From dietary fiber to host physiology: [21]摇 HIIPPALA K, JOUHTEN H, RONKAINEN A, et al.
short鄄chain fatty acids as key bacterial metabolites[J]. The potential of gut commensals in reinforcing intestinal
Cell, 2016, 165(6): 1332 - 1345. barrier function and alleviating inflammation[J]. Nutri鄄
[19]摇 DIMIDI E, CHRISTODOULIDES S, SCOTT S M, et al. ents, 2018, 10(8): 988.
Mechanisms of action of probiotics and the gastrointesti鄄 [22]摇 ZHOU W, GUO R, GUO W, et al. Monascus yellow,
nal microbiota on gut motility and constipation [ J]. red and orange pigments from red yeast rice ameliorate
Advances in Nutrition, 2017, 8(3): 484 - 494. lipid metabolic disorders and gut microbiota dysbiosis in
[20]摇 ZHAO L, ZHANG Q, MA W, et al. A combination of Wistar rats fed on a high鄄fat diet[J]. Food & Function,
quercetin and resveratrol reduces obesity in high鄄fat diet鄄 2019, 10(2): 1073 - 1084.

Effect of Non鄄Viable Lactobacillus paracasei L9 in

Normal Temperature Yogurt on Modulating Gut Microbiota
and Relieving Constipation

1 2 1 3 4 1,*
WANG Ran ,摇 LI Guihua ,摇 WANG Pengjie ,摇 LIU Li ,摇 LIU Zhilin ,摇 ZHANG Yan
(1郾 Department of Nutrition and Health, China Agricultural University, Beijing 100083,China;
2郾 College of Food Science and Nutritional Engineering,China Agricultural University, Beijing 100083,China;
3郾 Heibei Technology Advanced Innovation Center for Livestock Food, Langfang 065201,China;
4郾 Beijing Heyiyuan Biotechnology Company Limited, Beijing 100089,China)

Abstract: In order to evaluate the effect of non鄄viable Lactobacillus paracasei L9 ( L9 ) in normal
temperature yogurt on relaxing constipation and modulating gut microbiota, sixty鄄one subjects with
constipation were recruited and divided into two groups, drinking normal temperature yogurt or yogurt
containing non鄄viable L9 for 28 days, respectively. Constipation鄄related symptoms, the content of short
chain fat acids (SCFAs) and variation of gut microbiota were analyzed. Compared to the group drinking
normal temperature yogurt, the results in group drinking yogurt with non鄄viable L9 were as follows: the
defecation frequency was significantly increased (P < 0郾 05), the defecation condition and consistency
scores were remarkably reduced (P < 0郾 01), the content of butyric acid was dramatically increased (P <
0郾 01), propionic acid and total acid were significantly increased ( P < 0郾 05), and bacterial species
producing SCFAs such as Blautia, Ruminococcus_2 and [Eubacterium] _hallii_group were significantly
increased. The results indicated that normal temperature yogurt with non鄄viable L9 could help to relieve
constipation and modulate gut microbiota, which might provide a theoretical basis for developing
functional foods containing non鄄viable L9.
Keywords: non鄄viable; Lactobacillus paracasei L9; normal temperature yogurt; relieving constipation;
gut microbiota

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