The “all-encompassing approach to food” proposes new development demands for the future of the food industry. As the food industry expands and upgrades, unsafe factors and their evolutionary methods will become more complex, bringing more daunting tasks for safety risk prevention and control. Only by ensuring the safety of business forms can the food industry develop healthily and smoothly. Currently, the contradiction between limited regulatory resources and power and the increasingly heavy and complex regulatory tasks in the food industry is becoming more prominent. Traditional regulatory methods are insufficient to meet the high-quality development needs of the food industry. Data-driven computer science and intelligent technology provide technological entry points for food industry regulation. Collecting various information in real time within the food industry chain to form “data intelligence” and developing smart regulatory technology for the food industry help to build a standardized, orderly, and collaboratively efficient food industry ecological environment, providing support for high-quality development of the food industry. The development process of smart regulation in the food industry from its inception to prosperity was introduced, the application of intelligent technology in the digital construction of the whole food industry chain and food regulatory system was analyzed, the future development direction taking safety as bottom line, focused on quality monitoring, nutritional analysis, and flavor assessment was pointed out, and the opportunities and challenges faced by smart regulation in the food industry was discussed. This paper aimed to provide technical references for the intelligent and high-quality development of food industry regulation.