In order to obtain the strains with activity of reducing the content of biogenic amine in Huangjiu, Saccharopolyspora strains in the fermentation process of Huangjiu was isolated and identified, and its biogenic amine degradation ability was explored. In this study, 37 Saccharopolyspora strains were isolated and identified from wheat Qu and fermented mash of Huangjiu. Using biogenic amine production and biogenic amine degrading ability as evaluation indexes, two Saccharopolyspora strains (F1902 and F2014) with low biogenic amine production and strong biogenic amine degrading ability were obtained. According to the identification of molecular biology, physiological and biochemical indicators, the two strains were identified as Saccharopolyspora hirsuta and Saccharopolyspora rosea, respectively. The two strains were fermented in the medium containing biogenic amines for 5 days at 37℃. The total biogenic amines degradation rates of the two strains were 76.41%±0.82% and 74.62%±0.84%, respectively. The ability of the two strains to degrade biogenic amines under different environmental conditions was further studied, the results showed that temperature, pH value and ethanol concentration all affected the growth of Saccharopolyspora and the ability of reducing biogenic amines. The optimum temperature and pH value for S. hirsuta F1902 and S. rosea F2014 to degrade biogenic amines was 30℃, and 7, respectively. And a certain biogenic amine degradation ability was still exerted in the presence of volume fraction 7% ethanol. The research might provide a theoretical basis for the control of biogenic amine content during the brewing process of Huangjiu by Saccharopolyspora and the development and utilization of Huangjiu as biological resources.