In this experiment, the effects of Gastrodin elata extract, Fagopyrum tataricum extract and their mixtures on the growth and extracellular polysaccharide synthesis of Grifola frondosa were studied. The dynamic changes of residual sugar (reducing sugar) content and pH value in the fermentation system after adding the compound solution were also detected. The results showed that the best effect was observed after addition of Gastrodin elata extract and Fagopyrum tataricum extract at concentrations of 7g/L and 5g/L, respectively. Compared with the blank group (without adding extract) and the single addition group(Gastrodin elata or Fagopyrum tataricum), the yield of extracellular polysaccharide in compounding group was increased by 49.08%, 13.76% and 33.88%, respectively,and the mycelial biomass was increased by 51.10%, 11.35% and 26.69%, respectively, which were significantly higher than those in the blank group (P<0.01) and the single addition group(P<0.05).Fermentation kinetics analysis showed that the growth of Grifola frondosa and the production of extracellular polysaccharides peaked on the 7th day, and the compounding group could consume more carbohydrate than the blank group to promote the synthesis of extracellular polysaccharides. Therefore, the active ingredients in Gastrodia elata and Fagopyrum tataricum can significantly promote the growth of Grifola frondosa and the synthesis of extracellular polysaccharides.