The oral cavity is a complex and complete micro-ecosystem. Various factors such as lifestyle and pathogenshave adversely affected oral microbiome and perturbed the symbiosis between the microbiome and host, and this micro-ecological disorder could cause dental caries, periodontitis, gingivitis, halitosis and other oral diseases. Probiotics are living microorganisms that have beneficial effects on human body. Traditionally, probiotics have been widely used in various fields such as functional food, medicine, health care, and animal feed. The most common usages of probiotics are to treat or prevent gastrointestinal infections and diseases, and improve intestinal health. In the recent decade, probiotics was suggested to be used for oral health purposes due to positive improvement of various oral diseases via inhibiting the growth of pathogenic bacteria, improving oral microbial flora, regulating oral immunity, etc. In this review, we summarized the potential mechanism of oral probiotics in oral diseases, and described the important issues of using oral probiotics in the prevention and treatment of oral diseases, as well as the future development trends and development directions of oral probiotics. These insights might help build a theoretical basis for deep study of oral probiotics and improving its development and application in food industry.