The aim of this study was to explore an approach to effectively degrade rice pesticide residue and integrate technologies concerning safety rice production. Using local leading rice varieties as test materials, effects of degradation on rice pesticide residues through the use of amino acid organic fertilizer were researched. The organic fertilizer was sprayed on leaves in seedling establishment period and five days prior to heading stage, respectively, with concentration diluted from 9000mL·hm-2 to 4500mL·hm-2 by adding 450kg water each time. In terms of rice varieties, when the use dosage was above 5400mL·hm-2 by adding 450kg water each time, the pesticide residues could not be detected in Deyou 4727 and Chuanyou 6203,When the use dosage was above 9000mL·hm-2 by adding 450kg water each time, the pesticide residues could not be detected in Yixiangyou 2115 and Fyou 498. The application of the organic fertilizer can effectively promote the degradation of rice pesticide residues.