Development of infant formula powder industry was hammered after the melamine incident in 2008, consumers’ skepticism of infant formula powder quality safety has continued till now. In order to improve the quality safety, a series of policies have been formulated by related departments of our state. After the establishment of China Food and Drug Administration, stricter regulations have been issued. Quality safety of infant formula powder has been significantly improved after efforts of government and companies. This review summarized quality safety condition of infant formula powder, analyzed regulatory policy of infant formula powder formulated by related departments, and discussed future trends.