Bubbles are widely existed in nature with its irreplaceable roles in the practical application and a large number of experimental researches have been conducted. Depending on the different diameters of bubbles, bubbles were divided into large bubbles, micro-bubbles, micro-nano-bubbles, nano-bubbles. In this study, the properties of micro-nano-bubbles were introduced base on the characteristics of small volume and longer residence time in water. The application and development prospects of the micro-nano-bubbles in fruits and vegetables were discussed and their applications in other fields were also suggested.