Effects of Russula polysaccharide on mice hepatic insufficiency were investigated in this study. The senile model mice were established by D-galactose and mice were treated by 75mg/L and 150mg/L Russula polysaccharide. After 8 weeks, liver index, serum and hepatic GSH-Px, SOD activity, MDA contents, Ca²⁺-ATPase activity and hematoxylin-eosin staining of mice were determined. The results showed that the treatment of 150mg/L Russula polysaccharide could increase liver index, GSH-Px and SOD activity, and decrease the MDA content, which could inhibit the aging of liver.