In the production of Luzhou-flavor spirit using solid fermentation, the spirit production and its flavor were affected by the quality of solid distillers’ grains directly, which was influenced by many factors. In this paper, three typical fermented grains, includes alcohol-producing, acid-producing and ester-producing grains for Luzhou-flavor spirit were introduced, and its sensory physical , chemical detections, and the factors affecting the production of alcohol and ester were also presented.