In the paper, the influencing factors of hawthorn juice deacidification using ion exchange resin were investigated. The ion exchange resin (D311) was selected as the optimal resin from seven resins. Temperature was not the major influencing factors for deacidification. The optimal adsorption conditions of D311 resin was flow rate of 100ml/h at room temperature. The optimum condition for D311 resin regeneration was 100mL 1mol/L NaOH with low flow rate. After many times of regeneration, the adsorption of total acid reduced 11.5% and the adsorption of flavonoids reduced 73.3%. The residual of flavonoids was 88.8%.