12 - 食品科学技术学报页

究[D]. 北京:中国疾病预防控制中心,2009.
[44]摇 Sihvonen L M, Jalkanen K, Huovinen E, et al. Clinical
isolates of Yersinia enterocolitica biotype 1A represent
two phylogenetic lineages with differing pathogenicity鄄re鄄
lated properties[ J]. BMC Microbiology, 2012,12:208
- 219.
[45]摇 Duan R, Liang J R, Shi J X, et al. Homology analysis
of pathogenic Yersinia Species Yersinia enterocolitica ,
Yersinia pseudotuberculosis, and Yersinia pestis based on
Multi locus sequence typing[J]. Journal of Clinical Mi鄄
crobiology, 2014, 52(4): 20 - 29.
Biological Characteristics and Molecular Typing Research
Progress of Yersinia enterocolitica
WU Qingping1 ,摇 HU Huijuan1,2 ,摇 ZHANG Jumei1
(1. State Key Laboratory of Applied Microbiology in South China ( Ministry鄄 Guangdong Province Jointly Breeding
Base) / Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application / Guangdong Open
Laboratory of Applied Microbiology , Guangdong Institute of Microbiology , Guangzhou 510070, China ;
2. School of Bioscience and Bioengineering / South China University of Technology, Guangzhou 510006, China)
Abstract: Yersinia enterocolitica is an important psychrophilic pathogenic bacterium in the intestines.
There are more than 60 serotypes in the world. The serotypes of the pathogenic strains are the bioserovars
3 / O: 3 and 2 / O: 9 type in China. Y. enterocolitica has six biotypes including 1A, 1B, 2, 3, 4, and 5.
Five biotypes among them have been identified being pathogenic and type 1B is high pathogenic. Mean鄄
while, type 1A has potential pathogenicity. The virulence factors are mainly ail , ystA , ystB , yadA, and
virF , which are usually used to determine Y. enterocolitica pathogenicity. Y enterocolitica is resistant to
penicillins and first generation cephalosporins naturally, and has different resistant rates to other antimi鄄
crobial agents and many strains with multiple drug resistance. Pulsed鄄field gel electrophoresis (PFGE),
repetitive elements sequence (REP / ERIC)鄄PCR, multi locus sequence typing (MLST) and so on are the
most frequently used methods for Y. enterocolitica molecular typing nowadays. ERIC鄄PCR typing has easy
operation and high polymorphism, which will also play a good role in the molecular typing of Y. enteroco鄄
litica.
Key words: Yersinia enterocolitica ; biological characteristics; molecular typing
( 责任编辑: 李摇 宁)
7
第 32 卷 第 4 期摇 摇 摇 摇 摇 摇 吴清平等: 食源性小肠结肠炎耶尔森氏菌生物学特性和分子分型研究进展