Focus on the problem of cadmium (Cd) enrichment in Boletus griseus, total Cd content in the B. griseus samples from three regions in Yunnan was investigated, and three B. griseus with different Cd contents (high, medium, and low) were selected to evaluated the bioaccessibility of Cd (Cd-BAc) in B. griseus by a more realizable and quantifiable in vitro whole biomimetic digestive method established in this study. The effects of five dietary nutrients, tannic acid, CaCl₂, proanthocyanins, Zn/Ca gluconate and rambutan peel polyphenols, on Cd-BAc were studied, and the edible health risk of Cd in B. griseus was assessed based on total Cd contents and Cd-BAc. The results showed that there were high Cd contents in 53 B. griseus samples. The Cd-BAc during the gastric digestion was 55.30%-59.36%. The Cd-BAc was decreased to 39.59%-52.86% due to significantly reduced dissolution in the weakly alkaline and nearly neutral environment of the small intestine. The Cd-BAc was further decreased to 21.41%-25.28% by large intestinal flora fermentation. The five dietary nutrients had little effects on Cd-BAc during the gastric digestion, but significantly reduced Cd-BAc during the small and large intestinal flora fermentation, of which CaCl₂ was the most effective. Based on the total Cd contents in B. griseus, the human Cd exposure risk hazard quotient (HQ) caused by medium Cd and high Cd content of B. griseus was 2.98 and 5.13, but considering Cd-BAc and the effects of five dietary nutrients, the HQ could be reduced to 0-0.37. The result indicated that the edible health risk of Cd in B. griseus was very high, and dietary nutrients could modulate its health risk to human by reducing its bioaccessibility in intestine. Therefore, dietary nutrients might be an effective strategy to control the health risks of Cd during the processing or consumption of foods with high Cd content. However, the effectiveness of this strategy requires further in vivo experimental verification.