An analytical method for simultaneous determination of organotins in food contact materials with different uses by gas chromatography-mass spectrometry was established. The derivatization conditions and detection conditions were optimized and the detection types of organotins were also extended. On the basis of 4 kinds of organtins detection (dibutyltin dichloride, tributyltin chloride, dioctyltin dichloride and triphenyltin chloride) of the current standard of SN/T 3938—2014 “food contact materials-polymers-determination of the organotin compounds-gas chromatography-mass spectrometry”, the detection types of organotins increased to 9 kinds (added:monobutyltin trichloride, tributyltin oxide, mono-n-octyltin trichloride, tetrabutyltin and tricyclohexyltin chloride), and the methodology validation experiments were completed. The good linear relationships were obtained with correlation coefficients of 0.9993-0.9995 in the range of 10-2000μg/L. The limits of detection and quantitation were 5-20μg/kg and 15-71μg/kg, respectively. The injection precisions were 1.07%-1.82%. The intermediate precisions were good, and the relative standard deviation (RSD) of the results detected by different laboratory technicians in different times were 1.52%-2.65%. The RSD of the detection results of durability were 1.51%-2.22%. In this study, 4 kinds of food contact materials with different uses were bought from the market and detected. These samples were made of PVC or plastic containing PVC, such as plastic wrap, heat preservation bag lining, place mat, and refrigerator storage box for dumplings, etc. The results showed that no organotins were detected in these 4 kinds of food contact materials. The recoveries and repeatability were good, the recoveries were 85.93%-117.39%, and the corresponding RSD were 1.12%-1.97%. The established method was highly sensitive, simple, reliable, and versatile, which could be applicable for the simultaneous detection of 9 kinds of organotins in food contact materials.