Corn is the world's and China's largest planted and most widely used crop,with the highest yield production among all the crops. According to the harvest parts and uses, corn can be divided into three types, which are grain corn, fresh corn and silage corn. Grain corn is one of the main products in China. This study points out that the main quality and safety problems of grain corn and its products in terms are mycotoxins contamination. Problems of pesticide residue and heavy metal pollution also exist to a certain extent. This study also give the corresponding control measures from the aspects of corn breeding and cultivation, including:1)Breeding new maize cultivars of wide adaptability and resistance, and taking active measures to prevent and control diseases and insect pests. 2) Breeding and recommending good maturity and quick dehydration cultivars suitable for grain harvesting, and drying timely and storing standardly. 3) Improving relevant test and standard systems. 4) Comprehensively preventing and controlling plant diseases and pests, and rationally using pesticides, fungicides, herbicides which is mainly through biological control supplemented by chemical control with low toxicity. 5) Strengthening standard farmland construction, and reducing nonpoint source pollution and the absorption and accumulation of heavy metals in corn.