The effects of sample-liquid ratio, extraction temperature, extraction time, and extraction power on the yield of flavanone from peanut shell were investigated using the single factor experiment and orthogonal test. The optimum technology condition for ultrasonic assisted extraction of flavanone from peanut shell was determined as followed:the ratio of sample to solvent 1∶30, extraction temperature 35℃, extraction time 40min, and extraction power 100W. The extraction yield of flavanone from peanut shell was 3.458% under the optimum condition.