Metabolites of Streptomyces sp. TD-1 were reported with obvious inhibiting effects to Fusarium moniliforme, Aspergillus nidulans, Penicillium verrucosum, Aspergillus ochraceus, Aspergillus flavus, Aspergillus niger, Aspergillus oryzae, Fusarium solani and Penicillum citrinum with the size of inhibition zone of about 10 mm. The metabolic chart of growth process of TD-1 strain showed that the growth amounted to the maximum, and the inhibition rates reached to 90% at the 6th day. Stability test showed that the antimicrobial compounds produced by TD-1 strain had good thermo and pH stability, and strong anti-UV ability.