Whole egg is rich in protein, fat, and many vitamins and minerals. It is a natural source of nutritional supplements, but high levels of phosphorus limit its use in the diet of patients with kidney disease. Activated carbon, hydrotalcite and diatomite were selected to dephosphorize the whole egg liquid, and the dephosphorization rate, protein loss rate and color difference were taken as the indexes, the optimum amount of adsorbent, adsorption time and adsorption temperature were optimized, and then, the adsorption isotherms, adsorption kinetics and adsorption thermodynamics of the three adsorbents in the whole egg liquid were fitted. The results showed that the optimum dosage of activated carbon was 8 g/L, adsorption time was 120 min and adsorption temperature was 35℃, while the optimum dosage of hydrotalcite was 8 g/L, adsorption time was 150 min and adsorption temperature was 35℃, and the optimum dosage of diatomite was 8 g/L, the adsorption time was 90 min and the adsorption temperature was 35℃. In the process of adsorption, hydrotalcite had the least loss of protein and the highest adsorption specificity for phosphoric acid groups. Activated carbon had the greatest effect on a*, diatomite had the greatest effect on b*, and all three adsorbents increased L*. The study of adsorption mechanism showed that hydrotalcite was adsorbed in the form of monolayer. Freundlich adsorption isotherm n of three adsorbents were all greater than 1. With the increase of adsorption temperature, the KF of activated carbon, hydrotalcite and diatomite increased gradually. The quasi-first-order kinetic model R2 of three adsorbents were lower, and fluctuated with the increase of temperature. The quasi-second-order kinetic model R2 of diatomite was higher, and the chemical adsorption degree of diatomite was higher. The ΔG of activated carbon, hydrotalcite and diatomite were all negative and the ΔH were greater than 0, which meant that the reaction was spontaneous and endothermic.