Page 56 - 201705

5 2 食品科学技术学报摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 摇 2017 年 9 月

2015, 15:72 - 83. Pharmacokinetics of curcumin conjugate metabolites in
[22]摇 PANELLA B, HIRSCHER M. Hydrogen physisorption in healthy human subjects[J]. Cancer Epidemiology Bio鄄
metal鄄organic porous crystals [ J]. Advanced Materials, markers & Prevention, 2008, 17(6):1411 - 1417.
2005, 17(5):538 - 541. [25]摇 DEMPE J S, SCHEERLE R K, PFEIFFER E, et al.
[23]摇 张民召, 孙洋, 魏海英. 两种方法合成的 MOFs 材料 Metabolism and permeability of curcumin in cultured
表征及吸附性能研究 [ J]. 广州化工, 2016 (4): caco鄄2 cells[J]. Molecular Nutrition & Food Research,
53 - 55. 2013,57(9):1543 - 1549.
ZHANG M Z, SUN Y, WEI H Y. Characterization and [26]摇 陈卫. 肠道菌群:膳食与健康研究的新视角[J]. 食
sorption performance of metal organic frameworks synthe鄄 品科学技术学报, 2015, 33(6):1 - 6.
sized by two different methods[J]. Guangzhou Chemical CHEN W. Gut microbiota—a new concern on health
Industry, 2016(4):53 - 55. regulation[J]. Journal of Food Science and Technology,
[24]摇 VAREED S K, KAKARALA M, RUFFIN M T, et al. 2015,33(6):1 - 6.

Study on MOF鄄5 Adsorption Curcumin and Digestion in

Gastrointestinal Tract

*
LIU Ya,摇 WANG Yu,摇 CHEN Yingying,摇 TIAN Zheng,摇 XU Chunming
(School of Food and Chemical Engineering / Beijing Higher Institution Engineering Research Center of Food
Additives and Ingredients/ Beijing Key Laboratory of Flavor Chemistry, Beijing Technology and
Business University, Beijing 100048,China)

Abstract: MOF鄄5 was prepared by a direct synthesis method. Effects of MOF鄄5 mass, curcumin concen鄄
tration, adsorption temperature and and adsorption time were investigated by the single - factor experi鄄
ment. Based on the results, the orthogonal test method was used to optimize the adsorption conditions.
The optimal adsorption rate of the complex was simulated in vitro, and the bioavailability of the complex
was studied. The best adsorption conditions were as follows: MOF鄄5 quality 0郾 4 g, curcumin concentra鄄
tion 0郾 20 mg / mL, adsorption temperature 30 益, and adsorption time 36 min. Under the optimal condi鄄
tions, the best adsorption rate was 94郾 57% . After the simulated gastrointestinal digestion, the average
release rate of curcumin in gastric juice was 48郾 93% . After passing through the digestive tract, the
average content of curcumin was 10郾 32% . Curcumin absorbed by MOF鄄5 was released in stomach and
absorbed in intestine.

Keywords: MOF鄄5; curcumin; gastrointestinal digestion; in vitro simulated digestion

(责任编辑:叶红波)